Short Communication Preliminary study on the central nervous system depressant effect of Picrorhiza kurrooa Royle. (Scrophulariaceae) in mice models
نویسندگان
چکیده
Picrorhiza kurrooa Royle. is a well known medicinal plant among the indigenous medical practitioners of India. Present study is the first time to report the activity on the central nervous system. Preliminary study of the hot water extract showed significant depressant activity on the hole board test as evidenced from the ambulation and head dipping scores. The extract showed better activity compared to diazepam on the duration of pentobarbital induced sleeping time.
منابع مشابه
Kutkins- A Review of Chemistry and Pharmacology
Kutkins are group of pharmacologically active compounds present in Picrorhiza kurroa Royle (Scrophulariaceae). Picrorhiza kurroa is traditionally known as kutki and has intense bitter taste. In Ayurveda Picrorhiza kurroa is a reputed remedy for the treatment of liver diseases. The chemical composition of the Picrorhiza has been studied and active constituents are group of iridoid glycosides kno...
متن کاملCNS Depressant Effect of the Crude Extract of the Flowering Top of Rosa damascena (Rosaceae)
The ethanol extract of the flowering top of Rosa damascena (Rosaceae) was assessed for neuropharmacological activities in mice using a number of experimental models. It significantly prolonged the pentobarbitone-induced sleeping time in mice, and showed mild to moderate central nervous system depressant activity when assessed by the hole cross and the open field tests in mice model when given...
متن کاملCultivation: A promising method for conserving Picrorhiza kurrooa
Himalayas are one of the greatest reservoirs of medicinal and aromatic plants, which has made people to use them for various health related problems. Due to their high medicinal potential, they are under high demand in national and international market. The ruthless extraction from the wild and illegal trade has contributed to endangerment of the plant. Picrorhiza kurrooa Royle ex Benth, a valu...
متن کاملEffect of Picrorhiza Kurroa Benth. in Acute Inflammation
The effect of the indigenous drug Picrorhiza kurrooa Benth was studied on experimental acute inflammation in rats. It was observed that Picrorhiza kurrooa at a dose of 100 mg/kg b.w. has significant (p<0.01) anti inflammatory effect with respect to control, vehicle and standard drug.
متن کاملPicroside II protects cardiomyocytes from hypoxia/reoxygenation-induced apoptosis by activating the PI3K/Akt and CREB pathways.
Picroside II, an iridoid glucoside found in the root of Picrorhiza scrophulariiflora Pennell (Scrophulariaceae), has been demonstrated to reduce apoptosis in neuronal cells and other cell types. However, whether picroside II has a protective effect against cardiomyocyte apoptosis is poorly understood. In the present study, we investigated the cardioprotective role of picroside II and the underl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2008